| Issue | #5 |
| Published | May 2006 |
| Cover Price | 2.99 USD; 4.25 CAD |
| Pages | 36 |
| Editing | Andy Schmidt; Molly Lazer (assistant); Aubrey Sitterson (assistant) |
| Characters | Siryn |
| Genre | Superhero |
| Pencils | Ryan Sook |
| Inks | Ryan Sook |
| Colors | Jose Villarrubia |
| Characters | Damian Tryp, Jr. |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Dennis Calero |
| Inks | Dennis Calero |
| Colors | Jose Villarrubia |
| Letters | Typeset |
| Notes | Recap of story up to date. |
| Characters | X-Factor [Siryn [Theresa Rourke Cassidy]; Rictor [Julio Esteban Richter]]; Candy; Villain: Doctor Leery |
| Synopsis | An intense tale of a struggle for survival as a terrified, mute, and badly injured Siryn finds herself at the mercy of a demented captor...and her only hope of rescue is in the person of a powerless Rictor! [per solicitation] |
| Genre | Superhero |
| Script | Peter David |
| Pencils | Dennis Calero |
| Inks | Dennis Calero |
| Colors | Jose Villarrubia |
| Letters | Cory Petit of Virtual Calligraphy |
| Pencils | Gabriele Dell'Otto |
| Inks | Gabriele Dell'Otto |
| Letters | Typeset |
| Notes | Peter David answers letters from readers; Preview of cover to X-Factor #6. |