| Issue | #22 |
| Published | December 2007 |
| Cover Price | 2.99 USD; 3.75 CAD |
| Pages | 36 |
| Editing | Stephen Wacker; Thomas Brennan (Assistant Editor) |
| Characters | She-Hulk |
| Genre | superhero |
| Pencils | Mike Deodato Jr. (signed) |
| Inks | Mike Deodate Jr. (signed) |
| Colors | Rain Beredo [as Rainier Beredo] |
| Characters | She-Hulk |
| Genre | superhero |
| Pencils | Ed McGuinness |
| Inks | Dexter Vines |
| Colors | Kelsey Shannon |
| Characters | She-Hulk (also appears as Jennifer Walters) |
| Genre | superhero |
| Pencils | Ed McGuinness |
| Inks | Ed McGuinness (?) |
| Colors | Jason Keith |
| Notes | Zombie variant cover. |
| Characters | She-Hulk (also appears as Jennifer Walters) |
| Genre | superhero |
| Pencils | John Buscema |
| Inks | John Buscema |
| Letters | typeset |
| Reprinted | from Savage She-Hulk, The (Marvel, 1980 series) #1 (February 1980) [illustration] |
| Characters | She-Hulk; Jazinda (a Skrull disguised as Jennifer Walters; revealed in the following issue); Hi-Lite [Rockwell "Rocky" Davis]; Absorbing Man [Carl "Crusher" Creel]; Titania |
| Genre | superhero |
| Script | Peter David |
| Pencils | Shawn Moll |
| Inks | Victor Olazaba |
| Colors | Rob Ro |
| Letters | Dave Sharpe |
| Synopsis | Peter David talks about taking over the series from Dan Slott. (No letters in this issue.) |
| Script | Peter David |
| Pencils | Mike Deodato Jr.; Ed McGuinness |
| Inks | Mike Deodato Jr.; Dexter Vines |
| Colors | Rain Beredo; Kelsey Shannon; Jason Keith |
| Letters | typeset |
| Notes | Page includes thumbnails of the cover and two variant covers for this issue. |