| Issue | #543 |
| Published | January 2007 |
| Cover Price | 3.99 USD |
| Pages | 68 |
| Editing | Tom Brevoort; Molly Lazer (Assistant); Aubrey Sitterson (Assistant) |
| Characters | Mr. Fantastic; Invisible Woman; Human Torch; The Thing |
| Genre | superhero |
| Pencils | Adi Granov (Painted) |
| Inks | Adi Granov (Painted) |
| Colors | Adi Granov (Painted) |
| Letters | Typeset |
| Characters | Mr. Fantastic; Invisible Woman; Human Torch; The Thing |
| Genre | superhero |
| Pencils | Adi Granov (Painted) |
| Inks | Adi Granov (Painted) |
| Colors | Adi Granov (Painted) |
| Letters | Typeset |
| Characters | Fantastic Four--Mr. Fantastic; Invisible Woman; Human Torch; The Thing; GUESTS: Franklin Richards; Valeria Richards; CAMEOS: Hank Pym; Black Panther; Namor, the Sub-Mariner; Dr. Doom; Willie Lumpkin; Wyatt Wingfoot; Spider-Man; Luke Cage; She-Thing [Sharon Ventura; Ms. Marvel]; She-Hulk; Conan O'Brien; Oprah Winfrey; Wolverine; Tony Stark [Iron Man]; Storm; CAMEO FLASHBACK: Galactus; Silver Surfer |
| Synopsis | While Ben, Johnny and the kids watch a retrospective of the Fantastic Four on Lateline, Reed and Sue try to settle their differences over the split that came between them during the Civil War; Returning home, they tell Ben and Johnny that they are taking a leave of absence from the team to work on their marriage and introduce them to their replacement members--the Black Panther and Storm. |
| Genre | superhero |
| Script | Dwayne McDuffie |
| Pencils | Mike McKone |
| Inks | Andy Lanning; Cam Smith |
| Colors | Paul Mounts |
| Letters | Virtual Calligraphy's Rus Wooton |
| Genre | superhero |
| Script | Molly Lazer; Lisa Kirby; Paul Ryan; Alan Davis; Tom DeFalco; Flo Steinberg; Roy Thomas; Mike Wieringo |
| Pencils | Michael Turner |
| Inks | Michael Turner |
| Colors | Peter Steigerwald |
| Letters | Typeset |
| Notes | Fan letters from Jack Kirby's daughter and creators who have worked on the Fantastic Four; Also presents a miniature cover for next issue. |
| Characters | Fantastic Four--Mr. Fantastic; Invisible Woman; Human Torch; The Thing; GUESTS: Franklin Richards; Stan Lee; Joe Quesada; VILLAINS: Mole Man; Moloids |
| Synopsis | On the 45th anniversary of the FF, Mole Man attacks the city and Reed refuses to fight him as nobody has made a big deal about their landmark achievement; Stan Lee shows up to save the day. |
| Genre | superhero |
| Script | Stan Lee |
| Pencils | Nick Dragotta |
| Inks | Mike Allred |
| Colors | Laura Allred |
| Letters | Virtual Calligraphy's Rus Wooton |
| Characters | Fantastic Four--Mr. Fantastic; Human Torch; The Thing; Crystal; GUESTS: Spider-Man; J. Jonah Jameson; Gorgon; Wyatt Wingfoot |
| Synopsis | Jameson sends Parker to get photos of Johnny Storm racing and, of course, the incident devolves into a battle between Spidey and the Torch. |
| Genre | superhero |
| Script | Paul Pope |
| Pencils | Paul Pope |
| Inks | Paul Pope |
| Colors | Jose Villarrubia |
| Letters | Virtual Calligraphy's Rus Wooton |