| Issue | #501 |
| Published | October 1953 |
| Cover Price | 0.10 USD |
| Pages | 36 |
| Editing | ? |
| Notes | Indicia title is "FRANCIS, THE FAMOUS TALKING MULE, No. 501." Code number is FRANCIS O.S. #501-5310. Copyright 1953 by United Feature Syndicate. |
| Characters | Francis the Talking Mule; Pete |
| Genre | fantasy |
| Pencils | Don Gunn |
| Inks | Don Gunn |
| Characters | Francis the Talking Mule; Pete |
| Synopsis | Francis thinks he's bidding on a horse blanket, but ends up with a buggy, instead. |
| Genre | fantasy |
| Pencils | Don Gunn |
| Inks | Don Gunn |
| Notes | Inside front cover; black and white. |
| Characters | Francis the Talking Mule; Pete |
| Synopsis | After hiring on a freighter, Francis and Pete end up in Africa. Francis is sentenced to death by a sheik because he is "full of evil spirits." Pete helps Francis escape by painting stripes on him so that the mule supposedly looks like a zebra. |
| Genre | fantasy |
| Pencils | Don Gunn |
| Inks | Don Gunn |
| Characters | Francis the Talking Mule; Pete |
| Synopsis | Francis pretends to be men in a mule costume so he can enter a restaurant. |
| Genre | fantasy |
| Pencils | Don Gunn |
| Inks | Don Gunn |
| Notes | Inside back cover; black and white. |
| Characters | Francis the Talking Mule; Pete |
| Synopsis | Pete convinces the manger of a theatrical agency to let Francis audition, but Francis has laryngitis and can't talk. |
| Genre | fantasy |
| Pencils | Don Gunn |
| Inks | Don Gunn |
| Notes | Back cover. |