| Issue | #21 |
| Published | August 2006 |
| Frequency | monthly except semi-monthly in August |
| Cover Price | 2.99 USD; 4.25 CAD |
| Pages | 40 |
| Editing | Aubrey Sitterson (Assistant Editor); Molly Lazer (Assistant Editor); Tom Brevoort (Editor); Joe Quesada (Editor-in-Chief) |
| Characters | Captain America [Steve Rogers] |
| Genre | Superhero |
| Pencils | Howard Chaykin |
| Inks | Howard Chaykin |
| Colors | Howard Chaykin |
| Letters | Typeset |
| Notes | Cover sports Civil War trade dress. |
| Reprinted | in Civil War: Avengers (Marvel, 2010 series) #[nn] |
| Characters | Captain America |
| Genre | superhero |
| Pencils | Howard Chaykin |
| Inks | Howard Chaykin |
| Letters | Typeset |
| Notes | Cover sports Secret Invasion trade dress. |
| Characters | Captain America [Steve Rogers]; Sentry; Spider-Man; Iron Man [Tony Stark]; Spider-Woman [Jessica Drew]; Luke Cage; Winter Soldier [Bucky Barnes]; Dum Dum Dugan; Falcon; Shocker; Yellowjacket [Hank Pym]; Maria Hill |
| Synopsis | Captain America flees from SHIELD and begins forming a resistance to the registration act. |
| Genre | Superhero |
| Script | Brian Michael Bendis |
| Pencils | Howard Chaykin |
| Inks | Howard Chaykin |
| Colors | Dave Stewart |
| Letters | Richard Starkings; Comicraft's Albert Deschesne |
| Reprinted | in New Avengers (Marvel, 2006 series) #5; in Civil War: Avengers (Marvel, 2010 series) #[nn] |