| Issue | #543 |
| Published | March 1954 |
| Cover Price | 0.10 USD |
| Pages | 36 |
| Editing | ? |
| Notes | Indicia title is "UNCLE WIGGILY, No. 543." Code number is U.W.O.S. #542-543. (Code number does not match issue number.) Copyright 1954 by Howard R. Garis. Last Uncle Wiggily Four Color issue. |
| Characters | Uncle Wiggily |
| Genre | funny animal |
| Pencils | Bill Weaver |
| Inks | Bill Weaver |
| Notes | Pencils and inks credits for this sequence from Alberto Becattini (May 14, 2007) |
| Characters | Cubby Bear; Butch Bear |
| Synopsis | Butch tries to find something to keep Cubby occupied. |
| Genre | funny animal |
| Pencils | Bill Weaver |
| Inks | Bill Weaver |
| Letters | Bill Weaver |
| Notes | Inside front cover; black and white. Pencils, inks, and letters credits for this sequence from Alberto Becattini (May 14, 2007) |
| Characters | Uncle Wiggily; Nurse Jane; Eenie Q. Wolverine; Flattail Beaver; Butch Bear |
| Synopsis | Eenie Q. Wolverine has an old Indian map that shows two golden totem poles are buried underneath Wiggily's house. He convinces Wiggily that the dam behind his house is cracked and that he should move his house immediately. |
| Genre | funny animal |
| Pencils | Bill Weaver |
| Inks | Bill Weaver |
| Letters | Bill Weaver |
| Notes | Pencils, inks, and letters credits for this sequence from Alberto Becattini (May 14, 2007) |
| Characters | Uncle Wiggily; Sammy; Pokey Turtle; Shaggy Wolf; The Bad Chaps [Fuzzy Fox; Bobby Bobcat] |
| Synopsis | When Shaggy and Pokey fight over a nickel, Wiggily seeks to solve the problem by hiding the coin so that whoever finds it first is the owner. |
| Genre | funny animal |
| Pencils | Bill Weaver |
| Inks | Bill Weaver |
| Letters | Bill Weaver |
| Notes | Pencils, inks, and letters credits for this sequence from Alberto Becattini (May 14, 2007) |
| Characters | Uncle Wiggily; Uncle Butter; Possie Possum; Roscoe Rooster; Grandpa Chuck; Butch Bear (cameo); Eenie Q. Wolverine (cameo); Scillery Scallery Alligator (villain); Muscles the Frog (villain) |
| Synopsis | Wiggily has to find out who is stealing eggs from Roscoe Rooster's chicken yard. |
| Genre | funny animal |
| Pencils | Bill Weaver |
| Inks | Bill Weaver |
| Letters | Bill Weaver |
| Notes | Story continues on inside back cover in black and white and concludes on the back cover in color. Pencils, inks, and letters credits for this sequence from Alberto Becattini (May 14, 2007) |