| Issue | #45 |
| Published | March 1959 |
| Cover Price | 0.25 USD |
| Pages | 52 |
| Editing | Albert B. Feldstein |
| Notes | Moxie Cowznofsky is named in letters column of issue #48. |
| Characters | Alfred E. Neuman; Moxie Cowznofsky |
| Genre | humor |
| Pencils | Kelly Freas (painted) |
| Inks | Kelly Freas (painted) |
| Colors | Kelly Freas (painted) |
| Notes | Moxie Cowznofsky is named in letters column of issue #48. |
| Synopsis | Parody of ad for Imperial Whiskey. |
| Genre | satire |
| Pencils | Kelly Freas (signed) |
| Inks | Kelly Freas (signed) |
| Letters | typeset |
| Notes | On inside front cover. |
| Pencils | various |
| Inks | various |
| Letters | typeset |
| Notes | Art is excerpts from this issue. Al Jaffee is credited as a writer, but it is unknown for which article(s). Melvin Cowznofski credited as an artist. |
| Characters | Sue Sullivan; Jerry De Muth; James C. Douglass; Ron Nowicki; Stu Brody; Sonny Mathias; Monroe Meisel; Gerry Waddell; Barney Gilmore; James E. Packer; Daniel Garcia; Jim Smythe |
| Synopsis | Awards in various categories of pop culture, rated by a panel of 12 real college humor magazine editors. |
| Genre | satire |
| Pencils | ? (photo); Wally Wood |
| Inks | ? (photo); Wally Wood |
| Letters | typeset |
| Characters | Alfred E. Neuman |
| Synopsis | House ad for hardcover book from Crown Publishers. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Letters | typeset |
| Synopsis | House ad for a MAD paperback book. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Letters | typeset |
| Characters | Kathy Gutekunst; Mr. Gutekunst |
| Synopsis | Letters of comment, mostly about issue #43. |
| Script | Albert B. Feldstein; Jim McPherson; Stephen Waldman; K. S. Marshall; John LeFrancois; Bernice Gottlieb; G. Brigham; Corey Ford; Jean Nickerson; Tony Bekas; Don Jones; Rex Rovang; The Strayers; Kathy Gutekunst; Richard Ryan |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Letters | typeset |
| Notes | Tony Bekas, Don Jones, and Rex Rovang are radio DJs noting they use material from MAD in their shows. |
| Synopsis | For October 2, 1958. |
| Genre | fact |
| Script | William M. Gaines |
| Letters | typeset |
| Notes | Publisher: William M. Gaines. Owner: E.C. Publications, Inc. [William M. Gaines; Jessie K. Gaines; Virginia E. MacAdie] |
| Characters | Alfred E. Neuman |
| Synopsis | House ad for pinups suitable for framing. |
| Pencils | Norman Mingo (painted) |
| Inks | Norman Mingo (painted) |
| Letters | typeset |
| Synopsis | House ad for MAD subscriptions. |
| Pencils | Larry Maleman ? (photo) |
| Inks | Larry Maleman ? (photo) |
| Letters | typeset |
| Characters | Gus Clutz |
| Synopsis | The problems of body-building. |
| Genre | satire |
| Pencils | Bob Clarke (signed) |
| Inks | Bob Clarke (signed) |
| Letters | typeset |
| Characters | Mr. Hotchkins; Mr. Hotchkins's boss |
| Synopsis | Hotchkins has some fun with fish before cutting off the heads, in his job at the butcher shop. |
| Genre | humor |
| Script | Don Martin (signed) |
| Pencils | Don Martin (signed) |
| Inks | Don Martin (signed) |
| Letters | typeset |
| Characters | Elihu Fribble |
| Synopsis | Bad advice for drivers on reading signs, hand signals, how to park, etc. |
| Genre | satire |
| Script | Tom Koch |
| Pencils | George Woodbridge (signed) |
| Inks | George Woodbridge (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Characters | Alley Oop; Mary Worth; Superman; Jiggs; Charlie Brown; Lucy Van Pelt; Schroeder; Linus Van Pelt; Snoopy; Dennis The Menace; Dennis's father; Dennis's mother; Popeye; Joe Palooka; Li'l Abner; Daisy Mae; Little Orphan Annie; Daddy Warbucks; Nancy; Sluggo; Morticia Addams; Pugsley Addams |
| Synopsis | How editorial cartoons would look if popular comic strips were used for the messages. |
| Genre | satire |
| Script | Gary Belkin |
| Pencils | Wally Wood |
| Inks | Wally Wood |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Characters | George Washington; James Arness; Amanda Blake |
| Synopsis | How ads might look if George Washington were creating them and using his "cannot tell a lie" philosophy. |
| Genre | satire |
| Pencils | Joe Orlando |
| Inks | Joe Orlando |
| Letters | typeset |
| Notes | Parodies of ads for Armstrong Tires; Pepsi-Cola; L & M Cigarettes; and Cadillac Automobiles. |
| Synopsis | A careful look at 12 of Mama Mia's canned products reveals they are all the same. |
| Genre | humor |
| Pencils | Joe Orlando (signed); Larry Maleman (photo) |
| Inks | Joe Orlando (signed); Larry Maleman (photo) |
| Letters | typeset |
| Synopsis | A comparison of sharp photos with blurred versions of the same photos and the poetic captions written for them. |
| Genre | humor |
| Pencils | Bob Clarke |
| Inks | Bob Clarke |
| Letters | typeset |
| Synopsis | Showing the past and current trends in automobile design and predictions of the future. |
| Genre | satire |
| Script | Dave Berg (signed) |
| Pencils | Dave Berg (signed) |
| Inks | Dave Berg (signed) |
| Letters | typeset |
| Synopsis | Ideas for new tattoo designs. |
| Genre | humor |
| Script | Tom Koch |
| Pencils | George Woodbridge (signed) |
| Inks | George Woodbridge (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Characters | Chet Huntley; David Brinkley; Bob Elliott; Ray Goulding; John; Aunt Martha; Ben; Matt; "Pills" Kowalski |
| Synopsis | What we might see if tv commercials were done in the style of the shows they appeared in. |
| Genre | satire |
| Script | Frank Jacobs |
| Pencils | Mort Drucker (signed) |
| Inks | Mort Drucker (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Characters | Alfred E. Neuman |
| Synopsis | Valentines that might be sent by businesses, combining advertising. |
| Genre | humor |
| Script | Frank Jacobs |
| Pencils | Bob Clarke (signed) |
| Inks | Bob Clarke (signed) |
| Letters | typeset |
| Notes | Final valentine depicts several MAD Magazine staffers. |
| Characters | Professor Bleent |
| Synopsis | The professor is so obnoxious that a man-eating plant burps after eating him. |
| Genre | humor |
| Script | Don Martin (signed) |
| Pencils | Don Martin (signed) |
| Inks | Don Martin (signed) |
| Letters | typeset |
| Characters | Lassie; Francine Scwine; Norman Vincint Spiel; Albrecht Von Neuman; Richard Nixon; Joe Dimaggio; Little Orphan Annie; Sandy; Alfred E. Neuman |
| Synopsis | Parody of LOOK Magazine. |
| Genre | satire |
| Script | Tom Koch |
| Pencils | Wally Wood (signed) |
| Inks | Wally Wood (signed) |
| Letters | typeset |
| Notes | Writer credit from "Totally MAD" CD collection. |
| Synopsis | A boy playing the "Ring The Bell" game at an amusement park demonstrates an unusual tactic. |
| Genre | humor |
| Script | Don Martin (signed) |
| Pencils | Don Martin (signed) |
| Inks | Don Martin (signed) |
| Letters | typeset |
| Characters | Wally Cox |
| Synopsis | Ad for cuff links designed by Wally Cox for Gauche Jewelry. |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Letters | type |
| Notes | Inside back cover. |
| Synopsis | Literary quotes (such as Shakespeare) linked to celebrities they might apply to. |
| Genre | humor |
| Letters | typeset |
| Notes | Appear in the margins of 23 pages of the issue. |
| Synopsis | Parody of ad for Sweethart Soap. |
| Genre | satire |
| Pencils | Kelly Freas (painted, signed) |
| Inks | Kelly Freas (painted, signed) |
| Colors | Kelly Freas (painted, signed) |
| Letters | typeset |