| Issue | #4 |
| Published | April - May 1953 |
| Cover Price | 0.10 USD |
| Pages | 36 |
| Editing | Harvey Kurtzman |
| Genre | humor |
| Script | Harvey Kurtzman ? |
| Pencils | Harvey Kurtzman (signed) |
| Inks | Harvey Kurtzman (signed) |
| Colors | Marie Severin |
| Script | Harvey Kurtzman; William Gaines |
| Letters | typeset |
| Notes | Letters from readers, with illustration. On inside front cover. |
| Characters | Superduperman [Clark Bent]; Lois Pain; Copy Boy; W. Twitchell; Captain Marbles [Billy Spafon] |
| Synopsis | Superduperman defeats Captain Marbles by causing Marbles to punch himself out, but Superduperman still can't make it with Lois. |
| Genre | satire |
| Pencils | Wally Wood (signed) |
| Inks | Wally Wood (signed) |
| Colors | Marie Severin |
| Notes | A parody of both Superman and Captain Marvel. |
| Reprinted | in Tales Calculated to Drive You Mad (EC, 1997 series) #2; Mad About the Fifties (Little, Brown & Co., 1997 series) #[nn]; Smithsonian Book of Comic-Book Comics, A (Smithsonian Institution / Harry N Abrams, 1981 Series) |
| Characters | Ramona Snarfle; Sheldon Flob; Rackstraw Him |
| Synopsis | Ramona is engaged to slobby, boring Flob but is smitten by the newcomer Rackstraw and follows Rackstraw into a life of crime. |
| Genre | satire |
| Pencils | Jack Davis (signed) |
| Inks | Jack Davis (signed) |
| Colors | Marie Severin |
| Notes | A parody of romance comics. |
| Reprinted | in Tales Calculated to Drive You Mad (EC, 1997 series) #2 |
| Colors | Marie Severin |
| Letters | typeset |
| Notes | House ad for E.C. comics. Printed as two ½ pages in bookend fashion around text story sequence. |
| Characters | Tumblers Tympannus; Tiberious O'Leary |
| Synopsis | Tumblers is temporarly paroled from prison to help free someone from a bank vault, but the police don't hold up their end of the bargain and he is reimprisoned. |
| Genre | humor |
| Script | Jerry DeFuccio |
| Colors | Marie Severin |
| Letters | typeset |
| Notes | Text story with an illustration. Writer credit from "Totally MAD" CD collection. |
| Reprinted | in Tales Calculated to Drive You Mad (EC, 1997 series) #2 |
| Characters | Cosmo McMoon |
| Synopsis | A fake letters column with Cosmo answering the letters. |
| Genre | satire; humor |
| Colors | Marie Severin |
| Letters | typeset |
| Notes | Text story with an illustration. Writer credit from "Totally MAD" CD collection. |
| Reprinted | in Tales Calculated to Drive You Mad (EC, 1997 series) #2 |
| Characters | Robin Hood; Big John; Sparkie; Alan Adaile; Friar Tuck; Little John; Happy; Sneezy; Sleepy; Doc; Dopey; Bashful; Grumpy; Maid Marion |
| Synopsis | After robbing a sheriff's posse, Robin Hood and his gang rob Big John and Sparkie of their last two cents. |
| Genre | satire |
| Pencils | John Severin (signed) |
| Inks | John Severin (signed) |
| Colors | Marie Severin |
| Notes | A parody of Robin Hood. |
| Reprinted | in Utterly Mad (Ballantine Books, 1956 Series) #178; Tales Calculated to Drive You Mad (EC, 1997 series) #2; |
| Characters | Margo Pain; Lamont Shadowskeedeeboomboom |
| Synopsis | Lamont kills Margo to preserve the secret of his identity. |
| Genre | satire |
| Pencils | Bill Elder (signed) |
| Inks | Bill Elder (signed) |
| Colors | Marie Severin |
| Notes | A parody of The Shadow. |
| Reprinted | in Tales Calculated to Drive You Mad (EC, 1997 series) #2; Brothers Mad, The (Ballantine Books, 1958 series) #U2105; Brothers Mad, The (Ballantine Books, 1958 series) #267K; Brothers Mad, The (Ballantine Books, 1958 series) #267 |
| Colors | ?; ? (photo) |
| Letters | typeset |
| Notes | Ad for Remco walkie-talkies and Magic Leaf tarnish remover. Drawn in comic style. |
| Characters | John Sill; George Jowett |
| Pencils | ? (photo) |
| Inks | ? (photo) |
| Letters | typeset |
| Notes | Ad for body-building method. On inside back cover. |
| Letters | typeset |
| Notes | Ad for auto repair manuals. On back cover. |