| Issue | #1 |
| Published | March 2001 |
| Cover Price | 2.99 USD; 4.50 CAD |
| Pages | 52 |
| Editing | Tom Brevoort (editor); Marc Sumerak (assistant editor) |
| Notes | Double-Size Issue. |
| Characters | Defenders [Sub-Mariner; Hulk [Bruce Banner]; Silver Surfer; Doctor Strange] |
| Genre | Superhero |
| Pencils | Erik Larsen (signed) |
| Inks | Klaus Janson (signed) |
| Colors | Liquid! Graphics (signed) |
| Characters | Defenders [Sub-Mariner; Hulk [Bruce Banner]; Silver Surfer; Doctor Strange; Hellcat]; Wong; Nighthawk; Val; Lord Vashti; Namorita; Alicia Masters; Gaea; Papa Hagg; Kyle Richmond; Patsy Walker; Fantastic Four [Mr. Fantastic; Thing; Human Torch [Johnny Storm]; Invisible Woman]; V: Night-Crawler; Yandroth; Ravagers of Creation; Toad Men; Borers; Mindless Ones from Dormammu's Dimension; Quasimodo |
| Synopsis | Yandroth captures Gaea and uses her power to bring countless menaces to the earth which releases enough power for Yandroth to manifest the Ravagers of Creation. The Defenders defeat them and Yandroth but with his dying breath he curses them. |
| Genre | Superhero |
| Script | Kurt Busiek; Erik Larsen |
| Pencils | Erik Larsen |
| Inks | Klaus Janson |
| Colors | Gregory Wright with Color Arts |
| Letters | Chris Eliopoulos |
| Script | Kurt Busiek; Erik Larsen |
| Letters | Typeset |
| Notes | Text piece about the history of the Defenders by Kurt Busiek and Erik Larsen. |
| Characters | Ultimate X-Men [Ultimate Wolverine; Ultimate Storm; Ultimate Colossus; Ultimate Cyclops; Ultimate Marvel Girl; Ultimate Beast]; Hulk [Bruce Banner]; Betty Ross Banner |
| Synopsis | "On sale next week" (11 Marvel titles), "Marvel Spotlight" (Ultimate X-Men #2 and Incredible Hulk #24), [Editorial] by Bill Rosemann. Appears between pages 10 and 11 of the story. |
| Genre | Superhero |
| Script | Bill Rosemann |
| Pencils | Adam Kubert; John Romita, Jr. |
| Inks | Richard Isanove; Klaus Janson |
| Letters | Typeset |
| Characters | Ultimate Wolverine |
| Genre | Superhero |
| Script | ? (promo copy) |
| Pencils | Adam Kubert |
| Inks | Richard Isanove |
| Letters | Typeset |
| Notes | House Advertisements (One-Pager) for current Marvel Comics series (subscription page with Wolverine illustration). Appears between pages 20 and 21 of the story. |
| Script | ? (ad copy) |
| Pencils | Various |
| Inks | Various |
| Colors | Various |
| Letters | Typeset |
| Notes | Total of 10 one-page advertisements for: Go-Gurt (snak, Yoplait), MVP (movie, Warner Brothers), Corn Nuts (snack, Nabisco), Starlog (magazine, Starlog), Joe Kubert Art School (education, Kubert School), Comics Mail Order (comics, mycomicshop.com), Comics Mail Order (comics, East Coast Comics), Comics Mail Order (comics, Mile High Comics), Milk (whymilk.com), Lloyd in Space (movie, Disney Channel). |